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5-HT Receptor 激动剂

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产品目录号: A11771


产品名 目录号 价格 数量
Prucalopride 5mg A11771-5
¥ 400.00
Prucalopride 10mg A11771-10
¥ 500.00
Prucalopride 25mg A11771-25
¥ 900.00
Prucalopride 50mg A11771-50
¥ 1,400.00
Prucalopride 10mM * 1mL in DMSO A11771-10mM-D
¥ 500.00



Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Prucalopride 发表的文献 (1)
  • Pierre Meschin, .et al. p11 modulates calcium handling through 5-HT?R pathway in rat ventricular cardiomyocytes., Cell Calcium, 2015, Dec;58(6):549-57 PMID: 26427584

Chemical Information

目录号 A11771
Mechanism of action Agonist
分子量 367.9
化学分子式 C18H26ClN3O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 179474-81-8
Synonyms Resolor
化学名称 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide


Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.
Target Value
5-HT4Aki: 2.5nM
5-HT4Bki: 8nM
5-HT3ki: 3.822μM
5-HT1Aki: >10μM
5-HT1Bki: >10μM
5-HT1Dki: >10μM
5-HT1Eki: >10μM
5-HT1Fki: >10μM
5-HT2Aki: >10μM
5-HT2Bki: >10μM
5-HT2Cki: >10μM
5-HT5Aki: >10μM
5-HT6ki: >10μM
5-HT7ki: >10μM


Solubility (25°C)* In vitro DMSO 60 mg/mL (163.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol 38 mg/mL (103.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.18 mL 135.91 mL 271.81mL
0.5 mM 5.44 mL 27.18 mL 54.36 mL
1 mM 2.72 mL 13.59 mL 27.18 mL
5 mM 0.54 mL 2.72 mL 5.44 mL

*The above data is based on the productmolecular weight 367.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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