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PX 12抑制缺氧诱导的HIF-1a转录活性（IC50 11 nM）和HT29和MCF-7肿瘤细胞的增殖（IC50分别为1.9和0.9 uM）。
靶点信息
| Trx-1 | ||||
| In vitro (25°C) | DMSO | 37 mg/mL (196.48 mM) | |
| Water | Insoluble | ||
| Ethanol | 37 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 53.1 mL | 265.52 mL | 531.04 mL |
| 0.5 mM | 10.62 mL | 53.1 mL | 106.21 mL |
| 1 mM | 5.31 mL | 26.55 mL | 53.1 mL |
| 5 mM | 1.06 mL | 5.31 mL | 10.62 mL |
*The above data is based on the productmolecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13831 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 188.31 |
| Formula | C7H12N2S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 141400-58-0 |
| Synonyms | IV-2, PX-12, PX12 |
| SMILES | CCC(C)SSC1=NC=CN1 |
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