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PX-478 HCl

促销

HIF-1alpha 抑制剂

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产品目录号: A14319

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PX-478 HCl 10mg A14319-10
¥ 1,400.00
PX-478 HCl 25mg A14319-25
¥ 2,500.00
PX-478 HCl 50mg A14319-50
¥ 3,500.00
PX-478 HCl 10mM * 1mL in DMSO A14319-10mM-D
¥ 850.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.

PX-478 HCl

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Chemical Information

目录号 A14319
Mechanism of action Inhibitor
分子量 394.12
化学分子式 C13H20Cl4N2O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 685898-44-6
Synonyms 0
SMILES code C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
化学名称 (S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride

生物活性

Description
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
Targets
HIF-1α

溶解性

Solubility (25°C)* In vitro DMSO 78 mg/mL (197.9 mM)
Water 78 mg/mL (197.9 mM)
Ethanol 78 mg/mL (197.9 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.37 mL 126.86 mL 253.73mL
0.5 mM 5.07 mL 25.37 mL 50.75 mL
1 mM 2.54 mL 12.69 mL 25.37 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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