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Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.25 mL | 111.27 mL | 222.53 mL |
| 0.5 mM | 4.45 mL | 22.25 mL | 44.51 mL |
| 1 mM | 2.23 mL | 11.13 mL | 22.25 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20786 |
|---|---|
| M. Wt | 449.37 |
| Formula | C18H13F6N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1315323-00-2 |
| Synonyms | Pyr-10; Pyr 10 |
| SMILES | O=S(C1=CC=C(C)C=C1)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O |
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