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Pyridostatin是一种G-quadruplexe稳定剂，无细胞试验中Kd为490 nM，其以一系列原癌基因，包括c-kit，K-ras 和 Bcl-2为靶点。可通过诱导复制和转录依赖性DNA损伤来促进人类癌细胞的生长停滞。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.76 mL | 83.8 mL | 167.61 mL |
| 0.5 mM | 3.35 mL | 16.76 mL | 33.52 mL |
| 1 mM | 1.68 mL | 8.38 mL | 16.76 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.35 mL |
*The above data is based on the productmolecular weight 596.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12717 |
|---|---|
| M. Wt | 596.64 |
| Formula | C31H32N8O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1085412-37-8 |
| Synonyms | RR-82, RR82, RR 82 |
| SMILES | NCCOC1=CC(NC(C2=NC(C(NC3=CC(OCCN)=C(C=CC=C4)C4=N3)=O)=CC(OCCN)=C2)=O)=NC5=C1C=CC=C5 |
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