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Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.4 mL | 106.98 mL | 213.95 mL |
| 0.5 mM | 4.28 mL | 21.4 mL | 42.79 mL |
| 1 mM | 2.14 mL | 10.7 mL | 21.4 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
*The above data is based on the productmolecular weight 467.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22453 |
|---|---|
| M. Wt | 467.39 |
| Formula | C21H28Cl2N6O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 875320-31-3 |
| Synonyms | JNJ-26481585 dihydrochloride,JNJ26481585 dihydrochloride,JNJ 26481585 dihydrochloride |
| SMILES | [H]Cl.O=C(C1=CN=C(N2CCC(CNCC3=CN(C)C4=C3C=CC=C4)CC2)N=C1)NO.[H]Cl |
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