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R1530

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Chk2, KDR, FGFR, Aurora A & Cdk2 抑制剂

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产品目录号: A13111

库存状态:中国现货中国现货

产品名 目录号 价格 数量
R1530 5mg A13111-5
¥ 600.00
R1530 10mg A13111-10
¥ 1,000.00
R1530 25mg A13111-25
¥ 2,000.00
R1530 50mg A13111-50
¥ 3,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2.

R1530

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Chemical Information

目录号 A13111
Mechanism of action Inhibitor
分子量 356.78
化学分子式 C18H14ClFN4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 882531-87-5
Synonyms R-1530, R 1530
SMILES code CC1=C2C(=NC3=CC(=C(C=C3C(=N2)C4=CC=CC=C4Cl)F)OC)NN1
化学名称 5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-2,10-dihydrobenzo[e]pyrazolo[4,3-b][1,4]diazepine

生物活性

Description
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.03 mL 140.14 mL 280.28mL
0.5 mM 5.61 mL 28.03 mL 56.06 mL
1 mM 2.8 mL 14.01 mL 28.03 mL
5 mM 0.56 mL 2.8 mL 5.61 mL

*The above data is based on the productmolecular weight 356.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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