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R547

促销

CDK 抑制剂

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产品目录号: A11190

库存状态:中国现货中国现货

产品名 目录号 价格 数量
R547 2mg A11190-2
¥ 700.00
R547 5mg A11190-5
¥ 1,200.00
R547 25mg A11190-25
¥ 4,000.00
R547 50mg A11190-50
¥ 7,200.00
R547 10mM * 1mL in DMSO A11190-10mM-D
¥ 2,140.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

R547

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Chemical Information

目录号 A11190
Mechanism of action Inhibitor
分子量 441.45
化学分子式 C18H21F2N5O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 741713-40-6
Synonyms R-547
SMILES code COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C
化学名称 [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone

生物活性

Description

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Targets
Target Value
CDK4/CyclinD1ki: 1nM
CDK1/CyclinBki: 2nM
CDK2/CyclinEki: 3nM
PKAki: >5μM
PKBki: >5μM
PKCαki: >5μM
PKCβki: >5μM
Fynki: >5μM
EphB3ki: >5μM
SGKki: >5μM
KDRki: >5μM
FGFRki: >5μM
EGFRki: >5μM
PDGFRki: >5μM
IGFRki: >5μM
Srcki: >5μM
FAKki: >5μM
AuroraAki: >5μM
GSK-3βki: 8μM
p38ki: >50μM
MAPK2ki: >50μM

溶解性

Solubility (25°C) * In vitro DMSO 60 mg/mL (135.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% hydroxyethyl cellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.65 mL 113.26 mL 226.53mL
0.5 mM 4.53 mL 22.65 mL 45.31 mL
1 mM 2.27 mL 11.33 mL 22.65 mL
5 mM 0.45 mL 2.27 mL 4.53 mL

*The above data is based on the productmolecular weight 441.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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