R547

Name: R547
SKU: A11190
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A11190

CDK 抑制剂

R547 是一种新型、选择性的细胞周期和转录周期蛋白依赖性激酶（CDKs）抑制剂（Ki 分别为 CDK1、CDK2 和 CDK4 的 1、3 和 1 nM），具有出色的体外细胞活性，能够抑制各种人类肿瘤细胞系的生长。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥420.00	现货
5mg	¥420.00	现货
10mg	¥770.00	现货
25mg	¥1,365.00	现货
50mg	¥2,660.00	现货
100mg	¥4,900.00	现货
500mg	¥11,795.00	现货
*10mM 1mL in DMSO**	¥840.00	现货
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Data Sheet

SDS

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生物活性

Discription

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Targets

Target	Value

产品信息

目录号	A11190
分子式	C18H21F2N5O4S
分子量	441.45
CAS号	741713-40-6
SMILES	COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C
其他名称	R-547
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	56 mg/mL (126.85 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% hydroxyethyl cellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.26 mL	226.53 mL
0.5 mM	4.53 mL	22.65 mL	45.31 mL
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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