Rademikibart (CBP-201) is a human monoclonal antibody specifically designed to target IL-4R??, exhibiting a high binding affinity with a dissociation constant (K_D) of 20.7 pM for human IL-4R?? epitopes. This antibody is characterized by its species specificity, as it does not interact with IL-4R?? from non-human species. Rademikibart effectively inhibits both IL-4 and IL-13-mediated STAT6 signaling pathways, as well as TF-1 cell proliferation and TARC production in peripheral blood mononuclear cells (PBMCs). This antibody is particularly relevant for research into moderate-to-severe Th2-mediated inflammatory diseases, providing a valuable tool for elucidating disease mechanisms and potential therapeutic targets.
Rademikibart (CBP-201) is a human monoclonal antibody specifically designed to target IL-4R??, exhibiting a high binding affinity with a dissociation constant (K_D) of 20.7 pM for human IL-4R?? epitopes. This antibody is characterized by its species specificity, as it does not interact with IL-4R?? from non-human species. Rademikibart effectively inhibits both IL-4 and IL-13-mediated STAT6 signaling pathways, as well as TF-1 cell proliferation and TARC production in peripheral blood mononuclear cells (PBMCs). This antibody is particularly relevant for research into moderate-to-severe Th2-mediated inflammatory diseases, providing a valuable tool for elucidating disease mechanisms and potential therapeutic targets.
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