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RAF265 (CHIR-265)



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产品目录号: A10773


产品名 目录号 价格 数量
RAF265 5mg A10773-5
¥ 1,200.00
RAF265 10mg A10773-10
¥ 2,000.00
RAF265 25mg A10773-25
¥ 3,800.00
RAF265 50mg A10773-50
¥ 6,500.00
RAF265 (CHIR-265) 10mM * 1mL in DMSO A10773-10mM-D
¥ 1,830.00



RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

RAF265 (CHIR-265)




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Chemical Information

目录号 A10773
Mechanism of action Inhibitor
分子量 518.4
化学分子式 C24H16F6N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 927880-90-8
Synonyms N/A
SMILES code CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
化学名称 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine


RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
VEGFR2 (Cell-free assay) B-Raf (Cell-free assay)
30 nM(EC50)3 nM-60 nM


Solubility (25°C) * In vitro DMSO 100 mg/mL (192.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (63.65 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.29 mL 96.45 mL 192.9mL
0.5 mM 3.86 mL 19.29 mL 38.58 mL
1 mM 1.93 mL 9.65 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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