Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

RAF265 (CHIR-265)

促销

RAF/VEGFR 抑制剂

0 Customer Reviews
产品目录号: A10773

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RAF265 5mg A10773-5
¥ 1,200.00
RAF265 10mg A10773-10
¥ 2,000.00
RAF265 25mg A10773-25
¥ 3,800.00
RAF265 50mg A10773-50
¥ 6,500.00
RAF265 (CHIR-265) 10mM * 1mL in DMSO A10773-10mM-D
¥ 1,830.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.

RAF265 (CHIR-265)

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10773
Mechanism of action Inhibitor
分子量 518.4
化学分子式 C24H16F6N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 927880-90-8
Synonyms N/A
SMILES code CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
化学名称 1-Methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine

生物活性

Description
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhibition of B-raf and c-Raf mutation to prevent cancers.
Targets
VEGFR2 (Cell-free assay) B-Raf (Cell-free assay)
30 nM(EC50)3 nM-60 nM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (192.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (63.65 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.29 mL 96.45 mL 192.9mL
0.5 mM 3.86 mL 19.29 mL 38.58 mL
1 mM 1.93 mL 9.65 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 RAF265 (CHIR-265) | RAF265 (CHIR-265) 供应商 | 订购 RAF265 (CHIR-265) | RAF265 (CHIR-265) 价格 | RAF265 (CHIR-265) 生产商 | 订单 RAF265 (CHIR-265) | RAF265 (CHIR-265) 代理商 | 购买 927880-90-8| 927880-90-8 供应商 | 订购 927880-90-8 | 927880-90-8 价格 | 927880-90-8 生产商 | 订单 927880-90-8 | 927880-90-8 代理商|buy RAF265 (CHIR-265) | RAF265 (CHIR-265) Supplier | purchase RAF265 (CHIR-265) | RAF265 (CHIR-265) cost | RAF265 (CHIR-265) manufacturer | order RAF265 (CHIR-265) | RAF265 (CHIR-265) distributor | buy 927880-90-8| 927880-90-8 Supplier | purchase 927880-90-8 | 927880-90-8 cost | 927880-90-8 manufacturer | order 927880-90-8 | 927880-90-8 distributor