Ramucirumab is a recombinant human IgG1 monoclonal antibody specifically designed to target and antagonize vascular endothelial growth factor receptor 2 (VEGFR-2). By binding to the extracellular domain of VEGFR-2, Ramucirumab effectively inhibits the interaction with its natural ligands, VEGF-A, VEGF-C, and VEGF-D. This blockade disrupts the downstream signaling pathways that promote angiogenesis, making Ramucirumab a potent angiogenesis inhibitor. It is primarily utilized in the clinical management of various solid tumors, leveraging its mechanism to impair tumor vascularization and growth.
Ramucirumab is a recombinant human IgG1 monoclonal antibody specifically designed to target and antagonize vascular endothelial growth factor receptor 2 (VEGFR-2). By binding to the extracellular domain of VEGFR-2, Ramucirumab effectively inhibits the interaction with its natural ligands, VEGF-A, VEGF-C, and VEGF-D. This blockade disrupts the downstream signaling pathways that promote angiogenesis, making Ramucirumab a potent angiogenesis inhibitor. It is primarily utilized in the clinical management of various solid tumors, leveraging its mechanism to impair tumor vascularization and growth.
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