产品详情

Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013.

溶解度 *

In vitro	DMSO	59 mg/mL (94.6 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.04 mL	80.18 mL	160.35 mL
0.5 mM	3.21 mL	16.04 mL	32.07 mL
1 mM	1.6 mL	8.02 mL	16.04 mL
5 mM	0.32 mL	1.6 mL	3.21 mL

*The above data is based on the productmolecular weight 623.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A17783
作用机制	Antagonist (拮抗剂)
M. Wt	623.63
Formula	C29H27F2N7O5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	737789-87-6
Synonyms	TAK385; TAK-385; TAK 385; Relugolix.
SMILES	O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)C)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1