Relugolix
目录号: A17783
GnRH 拮抗剂
Relugolix 是一种新型的非肽类、口服活性的促性腺激素释放激素（GnRH）拮抗剂，其在含40%胎牛血清的条件下的IC50为0.33 nM，TAK-385与TAK-013相比具有更高的亲和力和强大的拮抗活性。
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生物活性
| Discription | Relugolix is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist with IC50 of 0.33 nM in the presence of 40% fetal bovine serum, TAK-385 possesses higher affinity and potent antagonistic activity compared with TAK-013. | |||||
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| Cell Research |
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产品信息
| 目录号 | A17783 |
|---|---|
| 分子式 | C29H27F2N7O5S |
| 分子量 | 623.63 |
| CAS号 | 737789-87-6 |
| SMILES | O=C(NOC)NC1=CC=C(C(S2)=C(CN(C)C)C(C(N3C4=NN=C(OC)C=C4)=O)=C2N(CC5=C(F)C=CC=C5F)C3=O)C=C1 |
| 其他名称 | TAK385; TAK-385; TAK 385; Relugolix. |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 59 mg/mL (94.6 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.04 mL | 80.18 mL | 160.35 mL |
| 0.5 mM | 3.21 mL | 16.04 mL | 32.07 mL |
| 1 mM | 1.6 mL | 8.02 mL | 16.04 mL |
| 5 mM | 0.32 mL | 1.6 mL | 3.21 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 737789-87-6 | 737789-87-6 供应商 | 737789-87-6 花费 | 737789-87-6 生产商 | 订购 737789-87-6 | 737789-87-6 代理商