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RepSox (SJN 2511)

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产品目录号: A11762

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RepSox (SJN 2511) 10mg A11762-10
¥ 900.00
RepSox (SJN 2511) 25mg A11762-25
¥ 2,000.00
RepSox (SJN 2511) 50mg A11762-50
¥ 3,500.00
RepSox (SJN 2511) 100mg A11762-100
¥ 6,000.00
RepSox (SJN 2511) 10mM * 1mL in DMSO A11762-10mM-D
¥ 650.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).

RepSox (SJN 2511)

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Chemical Information

目录号 A11762
Mechanism of action N/A
分子量 287.32
化学分子式 C17H13N5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 446859-33-2
Synonyms E-616452, SJN 2511, ALK 5 inhibitor
SMILES code CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
化学名称 2-(3-(6-Methylpyridine-2-yl)-1H-pyr?azol-4-yl)-1,5-naphthyridine

生物活性

Description
RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
Targets
TGFβR1(ALK5) (Cell-free assay)
4 nM

溶解性

Solubility (25°C)* In vitro DMSO 57 mg/mL (198.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.8 mL 174.02 mL 348.04mL
0.5 mM 6.96 mL 34.8 mL 69.61 mL
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL

*The above data is based on the productmolecular weight 287.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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