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RG7112

selective p53-MDM2 抑制剂

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产品目录号: A11523

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RG7112 5mg A11523-5
¥ 1,200.00
RG7112 10mg A11523-10
¥ 2,100.00
RG7112 50mg A11523-50
¥ 6,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

RG7112

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Chemical Information

目录号 A11523
Mechanism of action Inhibitor
分子量 727.78
化学分子式 C38H48Cl2N4O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 939981-39-2
Synonyms RG-7112, RG 7112, RO5045337
SMILES code CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
化学名称 [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone

生物活性

Description
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.74 mL 68.7 mL 137.4mL
0.5 mM 2.75 mL 13.74 mL 27.48 mL
1 mM 1.37 mL 6.87 mL 13.74 mL
5 mM 0.27 mL 1.37 mL 2.75 mL

*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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