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selective p53-MDM2 抑制剂

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产品目录号: A11523


产品名 目录号 价格 数量
RG7112 5mg A11523-5
¥ 1,200.00
RG7112 10mg A11523-10
¥ 2,100.00
RG7112 50mg A11523-50
¥ 6,400.00



RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.





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Chemical Information

目录号 A11523
Mechanism of action Inhibitor
分子量 727.78
化学分子式 C38H48Cl2N4O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 939981-39-2
Synonyms RG-7112, RG 7112, RO5045337
SMILES code CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
化学名称 [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone


RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.74 mL 68.7 mL 137.4mL
0.5 mM 2.75 mL 13.74 mL 27.48 mL
1 mM 1.37 mL 6.87 mL 13.74 mL
5 mM 0.27 mL 1.37 mL 2.75 mL

*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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