RG7112
目录号: A11523
selective p53-MDM2 抑制剂
RG7112 是首个临床级小分子 MDM2 抑制剂，设计用于占据 MDM2 的 p53 结合口袋。
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生物活性
| Discription | RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. | |||||
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| Cell Research |
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产品信息
| 目录号 | A11523 |
|---|---|
| 分子式 | C38H48Cl2N4O4S |
| 分子量 | 727.78 |
| CAS号 | 939981-39-2 |
| SMILES | CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl |
| 其他名称 | RG-7112, RG 7112, RO5045337 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 97 mg/mL (133.55 mM) | |
| Water | Insoluble | ||
| Ethanol | 97 mg/mL (133.55 mM) | ||
| In vivo | 1% CMC Na | 13 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.74 mL | 68.7 mL | 137.4 mL |
| 0.5 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 1 mM | 1.37 mL | 6.87 mL | 13.74 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.75 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 939981-39-2 | 939981-39-2 供应商 | 939981-39-2 花费 | 939981-39-2 生产商 | 订购 939981-39-2 | 939981-39-2 代理商