RI-1
目录号: A13187
RAD51 抑制剂 II
RI-1 是一种小分子，它抑制中心重组蛋白 RAD51。RI-1 在人类细胞中特异性地减少基因转换，同时刺激单链退火。RI-1 与 RAD51 蛋白表面的半胱氨酸319位点共价结合，这可能会破坏 RAD51 单体在 DNA 上聚合成丝状体时所使用的界面。
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生物活性
| Discription | RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. | ||
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产品信息
| 目录号 | A13187 |
|---|---|
| 分子式 | C14H11Cl3N2O3 |
| 分子量 | 361.61 |
| CAS号 | 415713-60-9 |
| SMILES | C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl |
| 其他名称 | RI1?? RI 1 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 48 mg/mL (132.74 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.65 mL | 138.27 mL | 276.54 mL |
| 0.5 mM | 5.53 mL | 27.65 mL | 55.31 mL |
| 1 mM | 2.77 mL | 13.83 mL | 27.65 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 415713-60-9 | 415713-60-9 供应商 | 415713-60-9 花费 | 415713-60-9 生产商 | 订购 415713-60-9 | 415713-60-9 代理商