Riliprubart (SAR445088) is a humanized monoclonal antibody targeting C1s, a critical enzyme in the proximal segment of the classical complement pathway. This antibody selectively binds to activated C1s, effectively preventing its enzymatic activity on substrates C4 and C2. By inhibiting these interactions, Riliprubart impedes the formation of the classical pathway C3 convertase, C4b2a, thus modulating the immune response. This specific inhibition mechanism makes Riliprubart a valuable tool for research into immune regulation and the pathophysiology of diseases mediated by the classical complement system.
Riliprubart (SAR445088) is a humanized monoclonal antibody targeting C1s, a critical enzyme in the proximal segment of the classical complement pathway. This antibody selectively binds to activated C1s, effectively preventing its enzymatic activity on substrates C4 and C2. By inhibiting these interactions, Riliprubart impedes the formation of the classical pathway C3 convertase, C4b2a, thus modulating the immune response. This specific inhibition mechanism makes Riliprubart a valuable tool for research into immune regulation and the pathophysiology of diseases mediated by the classical complement system.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
