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Risperidone (Risperdal)是一种非典型的抗精神病药，用于治疗精神分裂症（包括青少年精神分裂症），精神分裂症，躁郁症的躁狂和躁狂状态，以及自闭症儿童的烦躁不安。
Targets
| Target | Value |
|---|---|
| 5-HT2A | ki: 0.17nM |
| α2c-adrenergicreceptor | ki: 1.3nM |
| D2receptor | ki: 3.57nM |
| D3receptor | ki: 3.6nM |
| D2LReceptor | ki: 4.16nM |
| D4receptor | ki: 4.66nM |
| D2SReceptor | ki: 4.73nM |
| α1A-adrenergicreceptor | ki: 5nM |
| 5-HT7 | ki: 6.6nM |
| α1B-adrenergicreceptor | ki: 9nM |
| 5-HT2C | ki: 12nM |
| 5-HT1B | ki: 14.9nM |
| α2a-adrenergicreceptor | ki: 16.5nM |
| H1receptor | ki: 20.1nM |
| 5-HT2B | ki: 61.9nM |
| 5-HT1D | ki: 84.6nM |
| α2b-adrenergicreceptor | ki: 108nM |
| H2receptor | ki: 120nM |
| 5-HT5A | ki: 206nM |
| 5-HT5A | ki: 206nM |
| D1receptor | ki: 244nM |
| D5receptor | ki: 290nM |
| 5-HT1A | ki: 423nM |
| 5-HT6 | ki: 2060nM |
| In vitro | DMSO | Warmed: 4 mg/mL (9.74 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (9.74 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.36 mL | 121.8 mL | 243.61 mL |
| 0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
| 1 mM | 2.44 mL | 12.18 mL | 24.36 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
*The above data is based on the productmolecular weight 410.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10797 |
|---|---|
| M. Wt | 410.5 |
| Formula | C23H27FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 106266-06-2 |
| Synonyms | R 64 766, Risperdal |
| SMILES | CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F |
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