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RITA (NSC 652287)

促销

p53 activator

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产品目录号: A11931

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RITA 5mg A11931-5
¥ 700.00
RITA 10mg A11931-10
¥ 1,200.00
RITA 25mg A11931-25
¥ 2,400.00
RITA 50mg A11931-50
¥ 4,000.00
RITA (NSC 652287) 10mM * 1mL in DMSO A11931-10mM-D
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.

RITA (NSC 652287)

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Chemical Information

目录号 A11931
Mechanism of action Activator
分子量 292.4
化学分子式 C14H12O3S2
Solubility DMSO
纯度 >99%
储存方式 at -20°C 2 years
CAS No. 213261-59-7
Synonyms NSC652287, p53 Activator III
SMILES code C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
化学名称 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol

生物活性

Description
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Targets
Mdm2 p53

溶解性

Solubility (25°C) * In vitro DMSO 58 mg/mL (198.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (27.36 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.2 mL 171 mL 342mL
0.5 mM 6.84 mL 34.2 mL 68.4 mL
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL

*The above data is based on the productmolecular weight 292.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Product NameSolubility(mg/mL)
WaterDMSOEthanol
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A10491JNJ 26854165<1 mg/mL66 mg/mL2 mg/mL
A11931RITA (NSC 652287)<1 mg/mL115 mg/mL4 mg/mL
A10522Lenalidomide (CC-5013)<1 mg/mL52 mg/mL<1 mg/mL
A10743Pomalidomide (CC-4047)<1 mg/mL55 mg/mL<1 mg/mL
A11163AT-406<1 mg/mL112 mg/mL112 mg/mL
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