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Rivaroxaban (Xarelto)

促销

Factor Xa 抑制剂

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产品目录号: A10800

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Rivaroxaban 5mg A10800-5
¥ 900.00
Rivaroxaban 10mg A10800-10
¥ 1,200.00
Rivaroxaban 25mg A10800-25
¥ 2,200.00
Rivaroxaban 50mg A10800-50
¥ 3,500.00
Rivaroxaban (Xarelto) 10mM * 1mL in DMSO A10800-10mM-D
¥ 1,370.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.

Rivaroxaban (Xarelto)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Rivaroxaban (Xarelto) 发表的文献 (2)
  • Dani?l Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
  • Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532每6539 PMID: 27550352

Chemical Information

目录号 A10800
Mechanism of action Inhibitor
分子量 435.9
化学分子式 C19H18ClN3O5S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 366789-02-8
Synonyms BAY 59-7939, Xarelto
SMILES code C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
化学名称 (S)-5-chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide

生物活性

Description
Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.
Targets
Factor Xa (Cell-free assay) Prothrombinase (Cell-free assay)
0.7 nM2.1 nM

溶解性

Solubility (25°C) * In vitro DMSO 87 mg/mL (199.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.94 mL 114.71 mL 229.41mL
0.5 mM 4.59 mL 22.94 mL 45.88 mL
1 mM 2.29 mL 11.47 mL 22.94 mL
5 mM 0.46 mL 2.29 mL 4.59 mL

*The above data is based on the productmolecular weight 435.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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