RKI-1447

目录号: A13067

ROCK1/ROCK2 inhibitor

RKI-1447 Chemical Structure

CAS NO. 1342278-01-6

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

库存: 现货

规格 价格 数量
5 mg
¥ 800.00
10 mg
¥ 1,200.00
25 mg
¥ 2,400.00
50 mg
¥ 4,400.00
10mM * 1mL in DMSO
¥ 1,110.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Targets
ROCK2 ROCK1
6.2 nM14.5 nM
In vitro (25°C) DMSO 65 mg/mL (199.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.64 mL 153.2 mL 306.4 mL
0.5 mM 6.13 mL 30.64 mL 61.28 mL
1 mM 3.06 mL 15.32 mL 30.64 mL
5 mM 0.61 mL 3.06 mL 6.13 mL

*The above data is based on the productmolecular weight 326.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13067
MECHANISM OF ACTION Inhibitor
M. Wt 326.37
Formula C16H14N4O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1342278-01-6
Synonyms RKI1447; RKI 1447. ROCK Inhibitor XIII
SMILES C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3

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