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RKI-1447

促销

ROCK1/ROCK2 抑制剂

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产品目录号: A13067

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RKI-1447 5mg A13067-5
¥ 800.00
RKI-1447 10mg A13067-10
¥ 1,200.00
RKI-1447 25mg A13067-25
¥ 2,400.00
RKI-1447 50mg A13067-50
¥ 4,400.00
RKI-1447 10mM * 1mL in DMSO A13067-10mM-D
¥ 1,110.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

RKI-1447

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Chemical Information

目录号 A13067
Mechanism of action Inhibitor
分子量 326.37
化学分子式 C16H14N4O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1342278-01-6
Synonyms RKI1447; RKI 1447. ROCK Inhibitor XIII
SMILES code C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3
化学名称 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

生物活性

Description
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Targets
ROCK2 ROCK1
6.2 nM14.5 nM

溶解性

Solubility (25°C) * In vitro DMSO 65 mg/mL (199.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.64 mL 153.2 mL 306.4mL
0.5 mM 6.13 mL 30.64 mL 61.28 mL
1 mM 3.06 mL 15.32 mL 30.64 mL
5 mM 0.61 mL 3.06 mL 6.13 mL

*The above data is based on the productmolecular weight 326.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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