RN-1747
目录号: A20615
TRPV4 激动剂
RN-1747 是一种选择性的瞬时受体电位阳离子通道亚家族V成员4(TRPV4)激动剂,其半最大有效浓度(EC50)值分别为 hTRPV4 0.77 μM、mTRPV4 4.0 μM 和 rTRPV4 4.1 μM。RN-1747 还能拮抗 TRPM8,其半抑制浓度(IC50)为 4 μM。
Discription | RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM. |
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目录号 | A20615 |
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分子式 | C17H18ClN3O4S |
分子量 | 395.86 |
CAS号 | 1024448-59-6 |
SMILES | O=S(N1CCN(CC2=CC=CC=C2)CC1)(C3=CC=C(Cl)C=C3[N+]([O-])=O)=O |
其他名称 | RN1747; RN 1747 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2