Ro 31-8220

目录号: A13514

PKC inhibitor

Ro 31-8220 Chemical Structure

CAS NO. 138489-18-6

Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,500.00
50 mg
¥ 4,200.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
Targets
PKCα PKCβ2 PKCβ1 PKCε PKCγ
5 nM14 nM24 nM24 nM27 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.3 mL 180.6 mL
0.5 mM 3.61 mL 18.06 mL 36.12 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13514
MECHANISM OF ACTION Inhibitor
M. Wt 553.7
Formula C25H23N5O2SCH3SO3H
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 138489-18-6
Synonyms BIM IX, Bisindolylmaleimide IX (mesylate)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O

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