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Ro 31-8220

促销

PKC 抑制剂

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产品目录号: A13514

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Ro 31-8220 10mg A13514-10
¥ 1,200.00
Ro 31-8220 25mg A13514-25
¥ 2,500.00
Ro 31-8220 50mg A13514-50
¥ 4,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

Ro 31-8220

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Ro 31-8220 发表的文献 (1)
  • Dao-Lai Zhang, .et al. Gq activity- and 汕-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851

Chemical Information

目录号 A13514
Mechanism of action Inhibitor
分子量 553.7
化学分子式 C25H23N5O2SCH3SO3H
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 138489-18-6
Synonyms BIM IX, Bisindolylmaleimide IX (mesylate)
SMILES code CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
化学名称 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester-methanesulfonate, carbamimidothioic acid

生物活性

Description
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
Targets
PKCα PKCβ2 PKCβ1 PKCε PKCγ
5 nM14 nM24 nM24 nM27 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.3 mL 180.6mL
0.5 mM 3.61 mL 18.06 mL 36.12 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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