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Ro 3306

促销

CDK1 抑制剂

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产品目录号: A14437

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Ro 3306 10mg A14437-10
¥ 1,000.00
Ro 3306 25mg A14437-25
¥ 1,800.00
Ro 3306 50mg A14437-50
¥ 3,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively).

Ro 3306

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Chemical Information

目录号 A14437
Mechanism of action Inhibitor
分子量 351.45
化学分子式 C18H13N3OS2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 872573-93-8
Synonyms Ro3306, Ro-3306
SMILES code C1=CC2=C(C=CC(=C2)/C=C/3\C(=O)N=C(S3)NCC4=CC=CS4)N=C1
化学名称 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

生物活性

Description
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively).
Targets
Target Value
CDK1ki: 20nM
PKCδki: 318nM
SGKki: 497nM
ERKki: 1980nM
PKAki: >2000nM
Aktki: >2000nM
PKCαki: >2000nM
Fynki: >2000nM
EphB3ki: >2000nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.45 mL 142.27 mL 284.54mL
0.5 mM 5.69 mL 28.45 mL 56.91 mL
1 mM 2.85 mL 14.23 mL 28.45 mL
5 mM 0.57 mL 2.85 mL 5.69 mL

*The above data is based on the productmolecular weight 351.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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