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Gamma-secretase 抑制剂

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产品目录号: A10802


产品名 目录号 价格 数量
RO4929097 5mg A10802-5
¥ 1,000.00
RO4929097 10mg A10802-10
¥ 1,800.00
RO4929097 50mg A10802-50
¥ 5,600.00
RO4929097 200mg A10802-200
¥ 13,800.00
RO4929097 10mM * 1mL in DMSO A10802-10mM-D
¥ 1,530.00



RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 RO4929097 发表的文献 (1)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168

Chemical Information

目录号 A10802
Mechanism of action Inhibitor
分子量 469.4
化学分子式 C22H20F5N3O3
Solubility DMSO>94mg/mL Water<1mg/mL Ethanol>16mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 847925-91-1
Synonyms N/A
SMILES code CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
化学名称 N1-[(7S)-6,7-Dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)propanediamide


RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM


Solubility (25°C) * In vitro DMSO 94 mg/mL (200.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (34.08 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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