RO4929097

目录号: A10802

Gamma-secretase inhibitor

RO4929097 Chemical Structure

CAS NO. 847925-91-1

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.

库存: 现货

规格 价格 数量
5 mg
¥ 1,000.00
10 mg
¥ 1,800.00
50 mg
¥ 5,600.00
200 mg
¥ 13,800.00
10mM * 1mL in DMSO
¥ 1,530.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
Targets
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM
In vitro (25°C) DMSO 94 mg/mL (200.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (34.08 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04 mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10802
MECHANISM OF ACTION Inhibitor
M. Wt 469.4
Formula C22H20F5N3O3
Solubility DMSO>94mg/mL Water<1mg/mL Ethanol>16mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 847925-91-1
Synonyms N/A
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

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