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RO5126766 (CH5126766)

Raf/MEK dual 抑制剂

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产品目录号: A14019

库存状态:中国现货中国现货

产品名 目录号 价格 数量
RO5126766 5mg A14019-5
¥ 1,400.00
RO5126766 10mg A14019-10
¥ 2,200.00
RO5126766 25mg A14019-25
¥ 4,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.

RO5126766 (CH5126766)

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Chemical Information

目录号 A14019
Mechanism of action Inhibitor
分子量 471.5
化学分子式 C21H18FN5O5S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 946128-88-7
Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
SMILES code CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
化学名称 3-?[[2-?[(Methylaminosulfony?l)?amino]?-?3-?fluoropyridin-?4-?yl]?methyl]?-?4-?methyl-?7-?[(pyrimidin-?2-?yl)?oxy]?-?2H-?1-?benzopyran-?2-?one

生物活性

Description
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
Targets
BRAF V600E BRAF CRAF MEK1
8.2 nM19 nM56 nM160 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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