RO5126766 (CH5126766)

目录号: A14019

Raf/MEK dual inhibitor

RO5126766 (CH5126766)

RO5126766 (CH5126766) Chemical Structure

CAS NO. 946128-88-7

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.

库存: 现货

规格 价格 数量
5 mg
¥ 1,400.00
10 mg
¥ 2,200.00
25 mg
¥ 4,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
Targets
BRAF V600E BRAF CRAF MEK1
8.2 nM19 nM56 nM160 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09 mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A14019
MECHANISM OF ACTION Inhibitor
M. Wt 471.5
Formula C21H18FN5O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 946128-88-7
Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

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