RO8994
目录号: A20865
MDM2 抑制剂
RO8994 是一系列高效选择性的螺[3.4]环吲哚酮小分子 MDM2 抑制剂,在 HTRF 结合实验中的 IC50 为 5 nM,在 MTT 增殖实验中的 IC50 为 20 nM。
Discription | RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). | |||||
---|---|---|---|---|---|---|
Cell Research |
|
目录号 | A20865 |
---|---|
分子式 | C31H31Cl2FN4O4 |
分子量 | 613.51 |
CAS号 | 1309684-94-3 |
SMILES | O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)NC5=CC=C(C(N)=O)C=C5OC |
其他名称 | RO 8994, RO-8994 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2