RO9021
目录号: A16686
ATP-competitive SYK 抑制剂
RO9021 是一种口服生物利用度高的新型 ATP 竞争性抑制剂，针对 SYK，平均 IC50 为 5.6 nM。
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生物活性
| Discription | RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM. |
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产品信息
| 目录号 | A16686 |
|---|---|
| 分子式 | C18H25N7O |
| 分子量 | 355.44 |
| CAS号 | 1446790-62-0 |
| SMILES | NC(C1=C(NC2=CC=C(C)C(C)=N2)C=C(N[C@H]3[C@@H](N)CCCC3)N=N1)=O |
| 其他名称 | RO 9021, RO-9021 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 5 mg/mL (14.06 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (19.69 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.13 mL | 140.67 mL | 281.34 mL |
| 0.5 mM | 5.63 mL | 28.13 mL | 56.27 mL |
| 1 mM | 2.81 mL | 14.07 mL | 28.13 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.63 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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