Roflumilast

目录号: A10804

PDE inhibitor

Roflumilast

Roflumilast Chemical Structure

CAS NO. 162401-32-3

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.

库存: 现货

规格 价格 数量
5 mg
¥ 550.00
10 mg
¥ 900.00
50 mg
¥ 1,800.00
100 mg
¥ 3,200.00
10mM * 1mL in DMSO
¥ 1,030.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
Targets
Target Value
PDE4B2IC50: 0.2nM
PDE4A1IC50: 0.7nM
PDE4B1IC50: 0.7nM
PDE4A4IC50: 0.9nM
PDE4C1IC50: 3nM
PDE4C2IC50: 4.3nM
In vitro (25°C) DMSO 81 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 15 mg/mL (37.2 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.8 mL 124.01 mL 248.02 mL
0.5 mM 4.96 mL 24.8 mL 49.6 mL
1 mM 2.48 mL 12.4 mL 24.8 mL
5 mM 0.5 mL 2.48 mL 4.96 mL

*The above data is based on the productmolecular weight 403.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10804
MECHANISM OF ACTION Inhibitor
M. Wt 403.2
Formula C17H14Cl2F2N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 162401-32-3
Synonyms Daxas, Daliresp
SMILES C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F

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