Rolinsatamab is a chimeric monoclonal antibody of the IgG1?? subtype, specifically designed to target the prolactin receptor (PRLR). This antibody can be conjugated to the pyrrolobenzodiazepine (PDB) dimer SGD-1882 through a cleavable maleimidocaproyl linker, creating the antibody-drug conjugate known as Rolinsatamab talirine. This conjugate features an average of two site-specific drug attachments at engineered cysteines (S239C). The linker incorporates a valine-alanine dipeptide, which serves as a cleavage site for cathepsin B, facilitating the release of the cytotoxic agent upon entry into targeted cells. Rolinsatamab talirine is primarily utilized in therapeutic applications where precise delivery of cytotoxic agents to cells expressing PRLR is required.
Rolinsatamab is a chimeric monoclonal antibody of the IgG1?? subtype, specifically designed to target the prolactin receptor (PRLR). This antibody can be conjugated to the pyrrolobenzodiazepine (PDB) dimer SGD-1882 through a cleavable maleimidocaproyl linker, creating the antibody-drug conjugate known as Rolinsatamab talirine. This conjugate features an average of two site-specific drug attachments at engineered cysteines (S239C). The linker incorporates a valine-alanine dipeptide, which serves as a cleavage site for cathepsin B, facilitating the release of the cytotoxic agent upon entry into targeted cells. Rolinsatamab talirine is primarily utilized in therapeutic applications where precise delivery of cytotoxic agents to cells expressing PRLR is required.
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