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Romidepsin (FK228 ,Depsipeptide)


HDAC 抑制剂

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产品目录号: A11920


产品名 目录号 价格 数量
Romidepsin (FK228 ,Depsipeptide) 1mg A11920-1
¥ 1,000.00
Romidepsin (FK228 ,Depsipeptide) 2mg A11920-2
¥ 1,600.00
Romidepsin (FK228 ,Depsipeptide) 5mg A11920-5
¥ 3,200.00
Romidepsin (FK228 ,Depsipeptide) 10mg A11920-10
¥ 5,000.00



Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.

Romidepsin (FK228 ,Depsipeptide)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Romidepsin (FK228 ,Depsipeptide) 发表的文献 (3)
  • Elena Netchiporouk, .et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/S谷zary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981每95998 PMID: 29221181
  • Ivan V. Litvinov, .et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res., 2014, 20(14): 3799每3808. PMID: 24850846
  • Ivan V Litvinov, .et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975每2982. PMID: 25486484

Chemical Information

目录号 A11920
Mechanism of action Inhibitor
分子量 540.7
化学分子式 C24H36N4O6S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 128517-07-7
Synonyms FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)
SMILES code C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C
化学名称 Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5)-disulfide


Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
HDAC1 (Cell-free assay) HDAC2 (Cell-free assay)
36 nM47 nM


Solubility (25°C) * In vitro DMSO 10 mg/mL (18.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.95mL
0.5 mM 3.7 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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