Romidepsin (FK228 ,Depsipeptide)

目录号: A11920

HDAC inhibitor

Romidepsin (FK228 ,Depsipeptide)

Romidepsin (FK228 ,Depsipeptide) Chemical Structure

CAS NO. 128517-07-7

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.

库存: 现货

规格 价格 数量
1 mg
¥ 1,000.00
2 mg
¥ 1,600.00
5 mg
¥ 3,200.00
10 mg
¥ 5,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.
Targets
HDAC1 (Cell-free assay) HDAC2 (Cell-free assay)
36 nM47 nM
In vitro (25°C) DMSO 10 mg/mL (18.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.95 mL
0.5 mM 3.7 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11920
MECHANISM OF ACTION Inhibitor
M. Wt 540.7
Formula C24H36N4O6S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 128517-07-7
Synonyms FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)
SMILES C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

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