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|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|Synonyms||FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)|
|化学名称||Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3-5)-disulfide|
|Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.|
|Solubility (25°C) *||In vitro||DMSO||10 mg/mL (18.49 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||18 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.49 mL||92.47 mL||184.95mL|
|0.5 mM||3.7 mL||18.49 mL||36.99 mL|
|1 mM||1.85 mL||9.25 mL||18.49 mL|
|5 mM||0.37 mL||1.85 mL||3.7 mL|
*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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