Romidepsin (FK228 ,Depsipeptide)

目录号: A11920

HDAC 抑制剂

Romidepsin (FK228 ,Depsipeptide)

Romidepsin (FK228 ,Depsipeptide) Chemical Structure

CAS NO. 128517-07-7

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2,IC50分别为1.6 nM和3.9 nM,但相对较弱地分别抑制HDAC4和HDAC6,IC50值为25 nM和79 nM。

库存: 现货

规格 价格 数量
1 mg
¥ 1,000.00
2 mg
¥ 1,600.00
5 mg
¥ 2,700.00
10 mg
¥ 5,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2,IC50分别为1.6 nM和3.9 nM,但相对较弱地分别抑制HDAC4和HDAC6,IC50值为25 nM和79 nM。
靶点信息
HDAC1 (Cell-free assay) HDAC2 (Cell-free assay)
36 nM47 nM
In vitro (25°C) DMSO 10 mg/mL (18.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.49 mL 92.47 mL 184.95 mL
0.5 mM 3.7 mL 18.49 mL 36.99 mL
1 mM 1.85 mL 9.25 mL 18.49 mL
5 mM 0.37 mL 1.85 mL 3.7 mL

*The above data is based on the productmolecular weight 540.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11920
作用机制 Inhibitor (抑制剂)
M. Wt 540.7
Formula C24H36N4O6S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 128517-07-7
Synonyms FK228, FR9N/A1228, depsipeptide, NSC 63N/A176)
SMILES C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C

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