Rubitecan
目录号: A22040
topoisomerase I 抑制剂
Rubitecan（RFS 2000），一种Camptothecin衍生物，是一种口服活性的拓扑异构酶 I 抑制剂，具有广泛的抗肿瘤活性，并诱导蛋白质连接的DNA单链断裂，从而阻断分裂细胞中的DNA和RNA合成。
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生物活性
| Discription | Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. | |||||
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产品信息
| 目录号 | A22040 |
|---|---|
| 分子式 | C20H15N3O6 |
| 分子量 | 393.35 |
| CAS号 | 91421-42-0 |
| SMILES | O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O |
| 其他名称 | RFS 2000, RFS2000, RFS-2000; 9-Nitrocamptothecin |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 51 mg/mL (129.65 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.42 mL | 127.11 mL | 254.23 mL |
| 0.5 mM | 5.08 mL | 25.42 mL | 50.85 mL |
| 1 mM | 2.54 mL | 12.71 mL | 25.42 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 91421-42-0 | 91421-42-0 供应商 | 91421-42-0 花费 | 91421-42-0 生产商 | 订购 91421-42-0 | 91421-42-0 代理商