Ruzaltatug is a humanized IgG1 monoclonal antibody engineered to specifically target ERBB3, also known as HER3. This receptor is a critical component of the EGFR family, known for its role in promoting tumor growth and conferring resistance to targeted cancer therapies. By binding to ERBB3, Ruzaltatug effectively inhibits key downstream signaling pathways, including PI3K/AKT, thereby potentially reducing cancer cell proliferation and enhancing cell death. Additionally, as a humanized IgG1 antibody, Ruzaltatug is capable of mediating antibody-dependent cellular cytotoxicity (ADCC), adding a mechanism that may contribute to its therapeutic efficacy. Recommended isotype controls for this antibody are Human IgG1 kappa, Isotype Control, to ensure accurate experimental results.
Ruzaltatug is a humanized IgG1 monoclonal antibody engineered to specifically target ERBB3, also known as HER3. This receptor is a critical component of the EGFR family, known for its role in promoting tumor growth and conferring resistance to targeted cancer therapies. By binding to ERBB3, Ruzaltatug effectively inhibits key downstream signaling pathways, including PI3K/AKT, thereby potentially reducing cancer cell proliferation and enhancing cell death. Additionally, as a humanized IgG1 antibody, Ruzaltatug is capable of mediating antibody-dependent cellular cytotoxicity (ADCC), adding a mechanism that may contribute to its therapeutic efficacy. Recommended isotype controls for this antibody are Human IgG1 kappa, Isotype Control, to ensure accurate experimental results.
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