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(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.09 mL | 60.43 mL | 120.85 mL |
| 0.5 mM | 2.42 mL | 12.09 mL | 24.17 mL |
| 1 mM | 1.21 mL | 6.04 mL | 12.09 mL |
| 5 mM | 0.24 mL | 1.21 mL | 2.42 mL |
*The above data is based on the productmolecular weight 827.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20169 |
|---|---|
| M. Wt | 827.47 |
| Formula | C40H63ClN4O10S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1835705-59-3 |
| Synonyms | VH032-PEG6-C4-Cl; VHL Ligand-Linker Conjugates 10; E3 ligase Ligand-Linker Conjugates 9 |
| SMILES | O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2 |
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