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(S,R,S)-AHPC TFA

(S,R,S)-AHPC TFA

Name: (S,R,S)-AHPC TFA
SKU: A19593

目录号: A19593

(S,R,S)-AHPC TFA Chemical Structure

CAS NO. 1631137-51-3

(S,R,S)-AHPC TFA (MDK7526 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (MDK7526 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

库存：现货

规格	价格	数量
5 mg	￥ 2,970.00
10 mg	￥ 5,120.00
50 mg	￥ 15,180.00
100 mg	￥ 30,360.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.36 mL	91.81 mL	183.62 mL
0.5 mM	3.67 mL	18.36 mL	36.72 mL
1 mM	1.84 mL	9.18 mL	18.36 mL
5 mM	0.37 mL	1.84 mL	3.67 mL

*The above data is based on the productmolecular weight 544.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A19593
M. Wt	544.59
Formula	C24H31F3N4O5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1631137-51-3
Synonyms	MDK7526 TFA, MDK 7526, MDK-7526; VH032-NH2 TFA; VHL ligand 1 TFA
SMILES	FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2