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S3I-201 (NSC 74859)


Stat3 抑制剂

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产品目录号: A10817


产品名 目录号 价格 数量
S3I-201 5mg A10817-5
¥ 400.00
S3I-201 10mg A10817-10
¥ 700.00
S3I-201 50mg A10817-50
¥ 1,750.00
S3I-201 100mg A10817-100
¥ 3,300.00
S3I-201 (NSC 74859) 10mM * 1mL in DMSO A10817-10mM-D
¥ 600.00



S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.

S3I-201 (NSC 74859)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 S3I-201 (NSC 74859) 发表的文献 (3)
  • Ethan L. Morgan, .et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle, PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659
  • Nishimura K, .et al. Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652
  • Soleimani AH, .et al. Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma, Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050

Chemical Information

目录号 A10817
Mechanism of action Inhibitor
分子量 365.4
化学分子式 C16H15NO7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 501919-59-1
Synonyms S3I201, NSC74859 , NSC-74859
SMILES code CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
化学名称 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid


S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.
STAT3 (Cell-free assay)
86 μM


Solubility (25°C) * In vitro DMSO 73 mg/mL (199.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO, 95% PEG 300 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.37 mL 136.84 mL 273.67mL
0.5 mM 5.47 mL 27.37 mL 54.73 mL
1 mM 2.74 mL 13.68 mL 27.37 mL
5 mM 0.55 mL 2.74 mL 5.47 mL

*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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