S3I-201 (NSC 74859)

Name: S3I-201 (NSC 74859)
SKU: A10817
Price: 245 CNY
Rating: 5 (4 reviews)

目录号: A10817

Stat3 抑制剂

4 篇发表文献

S3I-201（NSC 74859）是一种新型的Stat3抑制剂，能够抑制体外的Stat3、Stat3复合体形成以及Stat3与DNA的结合活性（IC50 = 86 ± 33 μM），并抑制依赖Stat3的转录活性。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥385.00	现货
25mg	¥630.00	现货
50mg	¥1,015.00	现货
100mg	¥1,925.00	现货
200mg	¥2,905.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用S3I-201 (NSC 74859)发表的4篇文献

Bae WJ, .et al. , J Exp Clin Cancer Res, 2019, 38:484 PMID: 31805999

Ethan L. Morgan, .et al. , PLoS Pathog, 2018, Apr; 14(4): e1006975 PMID: 29630659

Nishimura K, .et al. , Biochem Biophys Res Commun, 2018, Jan 1;495(1):1317-1321 PMID: 29191652

Soleimani AH, .et al. , Drug Deliv Transl Res, 2017, Aug;7(4):571-581 PMID: 28290050

生物活性

Discription

S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ?? 33 μM) and Stat3-dependent transcriptional activities.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10817
分子式	C16H15NO7S
分子量	365.4
CAS号	501919-59-1
SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
其他名称	S3I201, NSC74859 , NSC-74859
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	66 mg/mL (180.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.37 mL	136.84 mL	273.67 mL
0.5 mM	5.47 mL	27.37 mL	54.73 mL
1 mM	2.74 mL	13.68 mL	27.37 mL
5 mM	0.55 mL	2.74 mL	5.47 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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