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S3I-201 (NSC 74859)

S3I-201 (NSC 74859)

Name: S3I-201 (NSC 74859)
SKU: A10817

目录号: A10817

Stat3 抑制剂

Product Citations (4)

S3I-201 (NSC 74859) Chemical Structure

CAS NO. 501919-59-1

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
10 mg	￥ 700.00
50 mg	￥ 1,750.00
100 mg	￥ 3,300.00
10mM * 1mL in DMSO	￥ 600.00

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生物活性

S3I-201(NSC 74859)是Stat3的新型抑制剂，可在体外抑制Stat3，Stat3复合物的形成以及Stat3-DNA结合活性（IC50 = 86±33 ?M）和Stat3依赖性转录活性。

靶点信息

STAT3 (Cell-free assay)
86 μM

溶解度 *

In vitro (25°C)	DMSO	66 mg/mL (180.64 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.37 mL	136.84 mL	273.67 mL
0.5 mM	5.47 mL	27.37 mL	54.73 mL
1 mM	2.74 mL	13.68 mL	27.37 mL
5 mM	0.55 mL	2.74 mL	5.47 mL

*The above data is based on the productmolecular weight 365.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10817
作用机制	Inhibitor (抑制剂)
M. Wt	365.4
Formula	C16H15NO7S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	501919-59-1
Synonyms	S3I201, NSC74859 , NSC-74859
SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O