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Sabutoclax

Bcl-2 抑制剂

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产品目录号: A12823

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Sabutoclax 5mg A12823-5
¥ 1,450.00
Sabutoclax 10mg A12823-10
¥ 2,500.00
Sabutoclax 25mg A12823-25
¥ 3,200.00
Sabutoclax 50mg A12823-50
¥ 6,750.00
Sabutoclax 10mM * 1mL in DMSO A12823-10mM-D
¥ 4,090.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

Sabutoclax

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Sabutoclax 发表的文献 (1)
  • Christopher D. Graham, .et al. BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells, Oncotarget, 2017, Jan 31; 8(5): 8670每8678 PMID: 28055968

Chemical Information

目录号 A12823
Mechanism of action Inhibitor
分子量 700.78
化学分子式 C42H40N2O8
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1228108-65-3
Synonyms BI-97C1,BI97C1
SMILES code CC1=C(C(=C2C=C(C(=C(C2=C1)C(=O)NC[C@H](C)C3=CC=CC=C3)O)O)O)C4=C(C=C5C(=C4O)C=C(C(=C5C(=O)NC[C@H](C)C6=CC=CC=C6)O)O)C
化学名称 [2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-, (1R)

生物活性

Description
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Targets
Mcl-1 Bcl-xL Bcl-2 Bfl-1
0.20 μM0.31 μM0.32 μM0.62 μM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL heating (142.69 mM)
Water <1 mg/mL (<1 mM)
Ethanol 54 mg/mL heating (77.05 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.7mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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