Salubrinal

目录号: A12676

eIF2α dephosphorylation 抑制剂

Salubrinal

Salubrinal Chemical Structure

CAS NO. 405060-95-9

Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂,可将真核翻译起始因子2亚基α(eIF2α)磷酸化。保护细胞免受内质网应激诱导的细胞凋亡(EC50?15 μM)。

库存: 现货

规格 价格 数量
10 mg
¥ 1,000.00
25 mg
¥ 2,000.00
50 mg
¥ 3,500.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 690.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂,可将真核翻译起始因子2亚基α(eIF2α)磷酸化。保护细胞免受内质网应激诱导的细胞凋亡(EC50?15 μM)。
靶点信息
eIF2α (Cell-free assay)
In vitro DMSO 86 mg/mL (179.23 mM)
Water Insoluble
Ethanol 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.84 mL 104.21 mL 208.42 mL
0.5 mM 4.17 mL 20.84 mL 41.68 mL
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL

*The above data is based on the productmolecular weight 479.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12676
作用机制 Inhibitor (抑制剂)
M. Wt 479.81
Formula C21H17N4OSCl3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 405060-95-9
SMILES C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

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