SANT-1

Name: SANT-1
SKU: A13095
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A13095

Sonic hedgehog 抑制剂

SANT-1 是一种强效的、能够渗透细胞的 Sonic hedgehog (Shh) 信号通路抑制剂；它是 smoothened 活性的高亲和力拮抗剂（KD = 1.2 nM）。在 Shh-LIGHT2 细胞中，SANT-1 抑制 smoothened 激动剂的效果，其 IC50 为 20 nM。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥280.00	现货
10mg	¥490.00	现货
25mg	¥840.00	现货
50mg	¥1,400.00	现货
100mg	¥2,520.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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Data Sheet

SDS

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生物活性

Discription

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13095
分子式	C23H27N5
分子量	373.5
CAS号	304909-07-7
SMILES	CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4
其他名称	SANT 1, SANT1
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	21 mg/mL (56.22 mM)
	Water	Insoluble
	Ethanol	20 mg/mL (53.54 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.77 mL	133.87 mL	267.74 mL
0.5 mM	5.35 mL	26.77 mL	53.55 mL
1 mM	2.68 mL	13.39 mL	26.77 mL
5 mM	0.54 mL	2.68 mL	5.35 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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