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SAR156497

Aurora Kinase 抑制剂

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产品目录号: A14382

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SAR156497 5mg A14382-5
¥ 3,500.00
SAR156497 10mg A14382-10
¥ 6,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.

SAR156497

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Chemical Information

目录号 A14382
Mechanism of action Inhibitor
分子量 468.5
化学分子式 C27H24N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1256137-14-0
Synonyms SAR-156497, SAR 156497
SMILES code O=C(C1=C2NC3=C(C(CCC3)=O)[C@@H](C4=CC=CC(OC5=NC6=CC=CC=C6N5)=C4)C2=CN1)OCC
化学名称 (S)-ethyl 9-(3-((1H-benzo[d]imidazol-2-yl)oxy)phenyl)-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate

生物活性

Description
SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A), 1 nM (Aurora B / incenp), 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP3A4 and PDE3 inhibition.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.34 mL 106.72 mL 213.45mL
0.5 mM 4.27 mL 21.34 mL 42.69 mL
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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