SAR245409 (XL765, Voxtalisib)

Name: SAR245409 (XL765, Voxtalisib)
SKU: A16276
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A16276

PI3K/mTOR dual 抑制剂

SAR245409（也称为XL765）是一种 PI3K/mTOR 双重激酶抑制剂，是一种口服生物利用度的小分子，针对 PI3K/mTOR 信号通路中的磷脂酰肌醇3激酶（PI3K）和哺乳动物雷帕霉素靶蛋白（mTOR）激酶，具有潜在的抗肿瘤活性。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥840.00	现货
25mg	¥1,715.00	现货
50mg	¥2,800.00	现货
100mg	¥4,095.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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Data Sheet

SDS

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生物活性

Discription

SAR245409 is a PI3K/mTOR dual kinase inhibitor XL765 is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity.

Targets

Target	Value

产品信息

目录号	A16276
分子式	C13H14N6O
分子量	270.29
CAS号	934493-76-2
SMILES	O=C1C(C2=NNC=C2)=CC3=C(C)N=C(N)N=C3N1CC
其他名称	Voxtalisib, XL765, SAR 245409, SAR-245409, XL 765, XL-765
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	53 mg/mL (196.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37 mL	184.99 mL	369.97 mL
0.5 mM	7.4 mL	37 mL	73.99 mL
1 mM	3.7 mL	18.5 mL	37 mL
5 mM	0.74 mL	3.7 mL	7.4 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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