SAR405

Name: SAR405
SKU: A21345

目录号: A21345

PIK3C3 isoform Vps34 inhibitor

SAR405 Chemical Structure

CAS NO. 1523406-39-4

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).

库存：现货

规格	价格	数量
2 mg	￥ 810.00
5 mg	￥ 1,620.00
10 mg	￥ 3,150.00
50 mg	￥ 9,270.00

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生物活性

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).

溶解度 *

In vitro (25°C)	DMSO	Warmed: 76 mg/mL (171.22 mM)
	Water	Insoluble
	Ethanol	76 mg/mL (171.22 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.53 mL	112.65 mL	225.3 mL
0.5 mM	4.51 mL	22.53 mL	45.06 mL
1 mM	2.25 mL	11.27 mL	22.53 mL
5 mM	0.45 mL	2.25 mL	4.51 mL

*The above data is based on the productmolecular weight 443.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21345
作用机制	Inhibitor (抑制剂)
M. Wt	443.85
Formula	C19H21ClF3N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1523406-39-4
Synonyms	SAR 405, SAR-405
SMILES	O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4