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Saracatinib (AZD0530)


Src/Abl 抑制剂

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产品目录号: A10108


产品名 目录号 价格 数量
Saracatinib 10mg A10108-10
¥ 600.00
Saracatinib 25mg A10108-25
¥ 900.00
Saracatinib 100mg A10108-100
¥ 2,200.00
Saracatinib 200mg A10108-200
¥ 3,900.00
Saracatinib (AZD0530) 10mM * 1mL in DMSO A10108-10mM-D
¥ 920.00



Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.

Saracatinib (AZD0530)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Saracatinib (AZD0530) 发表的文献 (3)
  • Chisato Naito, .et al. Facilitatory effects of fetuin-A on atherosclerosis, Atherosclerosis, 2016, Mar;246:344-51 PMID: 26828753
  • Kenta Maruyama, .et al. 5-Azacytidine-induced Protein 2 (AZI2) Regulates Bone Mass by Fine-tuning Osteoclast Survival, J Biol Chem, 2015, Apr 10; 290(15): 9377每9386 PMID: 25691576
  • Amanda L Jackson, .et al. Emerging therapies: angiogenesis inhibitors for ovarian cancer, Expert Opin Emerg Drugs, 2015, Jun;20(2):331-46 PMID: 26001052

Chemical Information

目录号 A10108
Mechanism of action Inhibitor
分子量 542.0
化学分子式 C27H32ClN5O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 379231-04-6
Synonyms AZD-0530
化学名称 N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine


Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
Target Value
c-SrcIC50: 2.7nM
LCKIC50: <4nM
c-YESIC50: 4nM
EGFR(L861Q)IC50: 4nM
LynIC50: 5nM
EGFR(L858R)IC50: 5nM
FynIC50: 10nM
FGRIC50: 10nM
BLKIC50: 11nM
v-AblIC50: 30nM
EGFRIC50: 66nM
c-KitIC50: 200nM
EphA2IC50: 236nM
CSKIC50: >1μM
PDGFRβIC50: >5μM
PDGFRαIC50: 10μM
CDK2IC50: 10μM
VEGFR3/FLT4IC50: >10μM
FGFR1IC50: >10μM
MEKIC50: 14μM
VEGFR1/FLT1IC50: >100μM


Solubility (25°C) * In vitro DMSO 100 mg/mL (184.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (184.49 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.45 mL 92.25 mL 184.5mL
0.5 mM 3.69 mL 18.45 mL 36.9 mL
1 mM 1.85 mL 9.23 mL 18.45 mL
5 mM 0.37 mL 1.85 mL 3.69 mL

*The above data is based on the productmolecular weight 542.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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