Sarilumab is a recombinant human monoclonal antibody of the immunoglobulin G1 subclass, specifically targeting the alpha subunit of the human interleukin-6 receptor (IL-6R??). As an antagonist to IL-6, Sarilumab binds with high affinity to IL-6R??, effectively inhibiting both cis and trans signaling pathways mediated by IL-6. This inhibition plays a crucial role in modulating inflammatory responses, making Sarilumab a valuable tool for investigating the pathophysiology and potential therapeutic interventions for rheumatoid arthritis.
Sarilumab is a recombinant human monoclonal antibody of the immunoglobulin G1 subclass, specifically targeting the alpha subunit of the human interleukin-6 receptor (IL-6R??). As an antagonist to IL-6, Sarilumab binds with high affinity to IL-6R??, effectively inhibiting both cis and trans signaling pathways mediated by IL-6. This inhibition plays a crucial role in modulating inflammatory responses, making Sarilumab a valuable tool for investigating the pathophysiology and potential therapeutic interventions for rheumatoid arthritis.
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