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SB 203580


p38 MAPK 抑制剂

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产品目录号: A10824


产品名 目录号 价格 数量
SB 203580 25mg A10824-25
¥ 500.00
SB 203580 50mg A10824-50
¥ 800.00
SB 203580 100mg A10824-100
¥ 1,200.00
SB 203580 200mg A10824-200
¥ 2,300.00
SB 203580 10mM * 1mL in DMSO A10824-10mM-D
¥ 670.00



SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

SB 203580




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 SB 203580 发表的文献 (4)
  • Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Uwada J, .et al. Activation of muscarinic receptors prevents TNF-汐-mediated intestinal epithelial barrier disruption through p38 MAPK, Cell Signal, 2017, Jul;35:188-196 PMID: 28412413
  • ZHIQIANG ZHANG, .et al. Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway., Mol Med Rep. , 2015, Jul;12(1):1499-505. PMID: 25815691
  • Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Chemical Information

目录号 A10824
Mechanism of action Inhibitor
分子量 377.4
化学分子式 C21H16FN3OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 152121-47-6
Synonyms SB-203580, SB203580
SMILES code CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
化学名称 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine


SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
p38 MAPK (THP-1 cells) PKB (THP-1 cells)
0.3 μM-0.5 μM3 μM-5 μM


Solubility (25°C)* In vitro DMSO 43 mg/mL (113.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.97mL
0.5 mM 5.3 mL 26.5 mL 52.99 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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