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SB 239063

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p38 MAPK 抑制剂

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产品目录号: A11562

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SB 239063 2mg A11562-2
¥ 600.00
SB 239063 5mg A11562-5
¥ 900.00
SB 239063 10mg A11562-10
¥ 1,600.00
SB 239063 25mg A11562-25
¥ 3,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.

SB 239063

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Chemical Information

目录号 A11562
Mechanism of action Inhibitor
分子量 368.4
化学分子式 C20H21FN4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 193551-21-2
Synonyms SB239063, SB-239063
SMILES code COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
化学名称 trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole

生物活性

Description
SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. SB 239063 reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo.
Targets
p38α p38β
44 nM44 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.72 mL 271.44mL
0.5 mM 5.43 mL 27.14 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

*The above data is based on the productmolecular weight 368.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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