SB-408124

目录号: A11567

OX Receptor Antagonist

SB-408124 Chemical Structure

CAS NO. 288150-92-5

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

库存: 现货

规格 价格 数量
10 mg
¥ 800.00
25 mg
¥ 1,600.00
50 mg
¥ 2,800.00
100 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 880.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
Targets
OX1 (membrane) OX1 (whole cell)
27 nM(Ki)57 nM(Ki)
In vitro (25°C) DMSO 36 mg/mL (101.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.3 mL 280.61 mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11567
MECHANISM OF ACTION Antagonist
M. Wt 356.37
Formula C19H18F2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 288150-92-5
Synonyms SB408124, SB 408124
SMILES CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F

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