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SB-408124

促销

OX Receptor 拮抗剂

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产品目录号: A11567

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SB-408124 10mg A11567-10
¥ 800.00
SB-408124 25mg A11567-25
¥ 1,600.00
SB-408124 50mg A11567-50
¥ 2,800.00
SB-408124 100mg A11567-100
¥ 5,000.00
SB-408124 10mM * 1mL in DMSO A11567-10mM-D
¥ 880.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

SB-408124

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Chemical Information

目录号 A11567
Mechanism of action Antagonist
分子量 356.37
化学分子式 C19H18F2N4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 288150-92-5
Synonyms SB408124, SB 408124
SMILES code CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F
化学名称 N-(6,8-Difluoro-2-methyl-4-quinolin?yl)-N'-[4-(dimethylamino)phenyl]urea

生物活性

Description
SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
Targets
OX1 (membrane) OX1 (whole cell)
27 nM(Ki)57 nM(Ki)

溶解性

Solubility (25°C) * In vitro DMSO 36 mg/mL (101.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.3 mL 280.61mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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