SB 525334
目录号: A10827
ALK 抑制剂
SB525334 是一种选择性的转化生长因子-β受体 I（ALK5, TGF-βRI）抑制剂（IC50 = 14.3 nM）。它能够抑制 TGF-β1 引起的 smad2/3 核定位和肾细胞中 TGF-βRI 诱导的 mRNA 表达。
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生物活性
| Discription | SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells | ||
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产品信息
| 目录号 | A10827 |
|---|---|
| 分子式 | C21H21N5 |
| 分子量 | 343.4 |
| CAS号 | 356559-20-1 |
| SMILES | CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3 |
| 其他名称 | SB-525334, SB525334 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 67 mg/mL (195.09 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL (195.09 mM) | ||
| In vivo | 5% DMSO+corn oil | 19 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.12 mL | 145.6 mL | 291.21 mL |
| 0.5 mM | 5.82 mL | 29.12 mL | 58.24 mL |
| 1 mM | 2.91 mL | 14.56 mL | 29.12 mL |
| 5 mM | 0.58 mL | 2.91 mL | 5.82 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 356559-20-1 | 356559-20-1 供应商 | 356559-20-1 花费 | 356559-20-1 生产商 | 订购 356559-20-1 | 356559-20-1 代理商