SB 525334

目录号: A10827

ALK 抑制剂

SB 525334 Chemical Structure

CAS NO. 356559-20-1

SB525334是转化生长因子-β受体I(ALK5,TGF-βRI)的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 900.00
50 mg
¥ 3,000.00
100 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

SB525334是转化生长因子-β受体I(ALK5,TGF-βRI)的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。
靶点信息
TGFβR1(ALK5) (Cell-free assay)
14.3 nM
In vitro (25°C) DMSO 68 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 68 mg/mL (198 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.12 mL 145.6 mL 291.21 mL
0.5 mM 5.82 mL 29.12 mL 58.24 mL
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10827
MECHANISM OF ACTION Inhibitor
M. Wt 343.4
Formula C21H21N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 356559-20-1
Synonyms SB-525334, SB525334
SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3

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