产品详情

生物活性

SB525334是转化生长因子-β受体I（ALK5，TGF-βRI）的选择性抑制剂 (IC50 = 14.3 nM)。抑制TGF-β1诱导的smad2/3核定位和TGF-βRI诱导的肾细胞mRNA表达。

靶点信息

TGFβR1(ALK5) (Cell-free assay)
14.3 nM

溶解度 *

In vitro (25°C)	DMSO	67 mg/mL (195.09 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (195.09 mM)
In vivo	5% DMSO+corn oil	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.12 mL	145.6 mL	291.21 mL
0.5 mM	5.82 mL	29.12 mL	58.24 mL
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10827
作用机制	Inhibitor (抑制剂)
M. Wt	343.4
Formula	C21H21N5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	356559-20-1
Synonyms	SB-525334, SB525334
SMILES	CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3