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SB 525334

促销

ALK 抑制剂

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产品目录号: A10827

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SB 525334 5mg A10827-5
¥ 500.00
SB 525334 10mg A10827-10
¥ 900.00
SB 525334 50mg A10827-50
¥ 3,000.00
SB 525334 100mg A10827-100
¥ 5,000.00
SB 525334 10mM * 1mL in DMSO A10827-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells

SB 525334

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Chemical Information

目录号 A10827
Mechanism of action Inhibitor
分子量 343.4
化学分子式 C21H21N5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 356559-20-1
Synonyms SB-525334, SB525334
SMILES code CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
化学名称

生物活性

Description
SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50 = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells
Targets
TGFβR1(ALK5) (Cell-free assay)
14.3 nM

溶解性

Solubility (25°C) * In vitro DMSO 68 mg/mL (198 mM)
Water <1 mg/mL (<1 mM)
Ethanol 68 mg/mL (198 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.12 mL 145.6 mL 291.21mL
0.5 mM 5.82 mL 29.12 mL 58.24 mL
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL

*The above data is based on the productmolecular weight 343.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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