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SB 743921


KSP 抑制剂

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产品目录号: A10828


产品名 目录号 价格 数量
SB 743921 5mg A10828-5
¥ 1,200.00
SB 743921 10mg A10828-10
¥ 2,200.00
SB 743921 50mg A10828-50
¥ 6,700.00
SB 743921 100mg A10828-100
¥ 9,500.00
SB 743921 10mM * 1mL in DMSO A10828-10mM-D
¥ 2,250.00



SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.

SB 743921




顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10828
Mechanism of action Inhibitor
分子量 553.5
化学分子式 C31H33N2O3.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 940929-33-9
Synonyms SB-743921, SB743921
SMILES code CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
化学名称 N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride


SB 743921, a second generation KSP inhibitor, is a highly potent and active therapeutic in preclinical models of cancer.
Target Value
KSP(MX1cells)IC50: 0.06nM
KSP(Colo205cells)IC50: 0.07nM
KSPki: 0.1nM
KSP(SKOV3cells)IC50: 0.2nM
KSP(MV522cells)IC50: 1.7nM
KSP(P388cells)IC50: 14.4nM


Solubility (25°C) * In vitro DMSO 111 mg/mL (200.53 mM)
Water 22 mg/mL (39.74 mM)
Ethanol 111 mg/mL (200.53 mM)
In vivo Saline pH5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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