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SB 743921是第二代KSP抑制剂，在癌症的临床前模型中是一种高效有效的治疗剂。
Targets
| Target | Value |
|---|---|
| KSP(MX1cells) | IC50: 0.06nM |
| KSP(Colo205cells) | IC50: 0.07nM |
| KSP | ki: 0.1nM |
| KSP(SKOV3cells) | IC50: 0.2nM |
| KSP(MV522cells) | IC50: 1.7nM |
| KSP(P388cells) | IC50: 14.4nM |
| In vitro (25°C) | DMSO | 103 mg/mL (186.08 mM) | |
| Water | 20 mg/mL (36.13 mM) | ||
| Ethanol | 103 mg/mL (186.08 mM) | ||
| In vivo | Saline pH5.0 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.07 mL | 90.33 mL | 180.67 mL |
| 0.5 mM | 3.61 mL | 18.07 mL | 36.13 mL |
| 1 mM | 1.81 mL | 9.03 mL | 18.07 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
*The above data is based on the productmolecular weight 553.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10828 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 553.5 |
| Formula | C31H33N2O3.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 940929-33-9 |
| Synonyms | SB-743921, SB743921 |
| SMILES | CC1=CC=C(C=C1)C(=O)N(CCCN)[C@@H](C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl |
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