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SB225002

促销

CXCR2 拮抗剂

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产品目录号: A14209

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SB225002 10mg A14209-10
¥ 700.00
SB225002 25mg A14209-25
¥ 1,400.00
SB225002 50mg A14209-50
¥ 2,200.00
SB225002 10mM * 1mL in DMSO A14209-10mM-D
¥ 650.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

SB225002

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Chemical Information

目录号 A14209
Mechanism of action Antagonist
分子量 352.14
化学分子式 C13H10BrN3O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 182498-32-4
Synonyms SB-225002, SB 225002
SMILES code C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
化学名称 N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea

生物活性

Description
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
Targets
CXCR2
22 nM

溶解性

Solubility (25°C)* In vitro DMSO 70 mg/mL (198.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL heating (8.51 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.4 mL 141.99 mL 283.98mL
0.5 mM 5.68 mL 28.4 mL 56.8 mL
1 mM 2.84 mL 14.2 mL 28.4 mL
5 mM 0.57 mL 2.84 mL 5.68 mL

*The above data is based on the productmolecular weight 352.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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