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SB265610

CXCR2 拮抗剂

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产品目录号: A14195

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SB265610 5mg A14195-5
¥ 900.00
SB265610 10mg A14195-10
¥ 1,500.00
SB265610 25mg A14195-25
¥ 3,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.

SB265610

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Chemical Information

目录号 A14195
Mechanism of action Antagonist
分子量 357.16
化学分子式 C14H9BrN6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 211096-49-0
Synonyms SB 265610,SB-265610
SMILES code C1=CC=C(C(=C1)NC(=O)NC2=CC=C(C3=NNN=C23)C#N)Br
化学名称 N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

生物活性

Description
SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28 mL 139.99 mL 279.99mL
0.5 mM 5.6 mL 28 mL 56 mL
1 mM 2.8 mL 14 mL 28 mL
5 mM 0.56 mL 2.8 mL 5.6 mL

*The above data is based on the productmolecular weight 357.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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