SB265610

目录号: A14195

CXCR2 antagonist

SB265610

SB265610 Chemical Structure

CAS NO. 211096-49-0

SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

SB 265610 is a nonpeptide, allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM) that prevents receptor activation by binding to a region distinct from the agonist binding site. It does not bind to the related CXCR1 receptor.1 It has been shown to prevent neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28 mL 139.99 mL 279.99 mL
0.5 mM 5.6 mL 28 mL 56 mL
1 mM 2.8 mL 14 mL 28 mL
5 mM 0.56 mL 2.8 mL 5.6 mL

*The above data is based on the productmolecular weight 357.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A14195
MECHANISM OF ACTION Antagonist
M. Wt 357.16
Formula C14H9BrN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 211096-49-0
Synonyms SB 265610,SB-265610
SMILES C1=CC=C(C(=C1)NC(=O)NC2=CC=C(C3=NNN=C23)C#N)Br

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